Daniel Amador-Noguez’s research program seeks to generate a quantitative and holistic understanding of how metabolic networks are regulated in microbes. He integrates systems-level approaches, especially LC-MS-based metabolomics, with computational modeling and genetic engineering to understand how metabolic fluxes are controlled and how microbes adapt their metabolism in response to environmental challenges and during developmental processes. His laboratory has several research areas, including: 1) metabolic regulation in biofuel producers, 2) metabolic remodeling during biofilm development, and 3) metabolism of intracellular pathogens and biochemical activities of the gut microbiome.

His current Great Lakes Bioenergy research seeks to advance understanding of metabolism in a variety of emerging biofuel producing microorganisms, including Z.mobilis, C.hermocellum, S.cerevisiae, and others.

With this work, Amador-Noguez aims to provide answers to fundamental questions in biology and to develop new approaches to quantitatively probe metabolic networks. His work will contribute to a holistic and quantitative understanding of microbial metabolism and reveal new flux control principles that allow rational control of metabolic activity and are widely applicable to microbial biotechnology and biomedical research.