Dave Keating's research group is part of the Microbial Synthetic Biology Lab (MiSynBio lab) within the Great Lakes Bioenergy Research Center (GLBRC). The lab is interested in understanding and improving the conversion of lignocellulose to biofuel. Much current work focuses on the Gram-negative bacterium Escherichia coli, due to its sophisticated genetics, well-understood physiology, and widespread use as an industrial microbe. Short-term research is focused on the construction of consolidated bioprocessing strains (CBP) capable of the degradation of lignocellulose, and subsequent fermentation of the liberated sugars to biofuel. Researchers then use CBP strains to better understand the current enzymatic and metabolic bottlenecks in cellulosic biofuel production.